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Nefazodone

CAT: 0957-E4952-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E4952-01Size:5 mg
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Description
Nefazodone is a selective antagonist of 5-HT2Areceptors and moderately inhibits serotonin and norepinephrine reuptake, enhancing 5-HT synaptic transmission. It is also a potent inhibitor of CYP3A4 with reduced anticholinergic, alpha-adrenolytic, and sedative effects, along with notable immunoprotective properties.
CAS Number
83366-66-9
Target
5-HT Receptor
Activity
Neuronal Signaling
Molecular Formula
C25H32ClN5O2
Storage Conditions
2 years -20°C liquid

Chemical Information

Nefazodone

Nefazodone is an aromatic ether, a member of triazoles, a N-alkylpiperazine, a N-arylpiperazine and a member of monochlorobenzenes. It has a role as an antidepressant, an analgesic, an alpha-adrenergic antagonist, a serotonergic antagonist and a serotonin uptake inhibitor.

CAS Number83366-66-9
PubChem CID4449
IUPAC Name2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-1,2,4-triazol-3-one
Molecular FormulaC25H32ClN5O2
Molecular Weight470.0
XLogP4.3
Topological Polar Surface Area51.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Heavy Atom Count33
Formal Charge0
Complexity649
SMILES
CCC1=NN(C(=O)N1CCOC2=CC=CC=C2)CCCN3CCN(CC3)C4=CC(=CC=C4)Cl
InChI
InChI=1S/C25H32ClN5O2/c1-2-24-27-31(25(32)30(24)18-19-33-23-10-4-3-5-11-23)13-7-12-28-14-16-29(17-15-28)22-9-6-8-21(26)20-22/h3-6,8-11,20H,2,7,12-19H2,1H3
InChIKey
VRBKIVRKKCLPHA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Nefazodone
CAS: 83366-66-9
CID: 4449
Formula: C25H32ClN5O2
MW: 470.0
Interactive 3D Structure
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View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight470.0
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count10
Exact Mass469.2244530
Monoisotopic Mass469.2244530
Topological Polar Surface Area51.6 Ų
Heavy Atom Count33
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP20883-01Nefazodone
FN26173-01Nefazodone hydrochloride
540313Nefazodone HCl
MBS6119298-01Methoxymethoxy Nefazodone
HY-119209R-01Nefazodone (Standard)

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