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RMC-4998

CAT: 0957-E1959-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E1959-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RMC-4998 is a tri-complex inhibitor that selectively targets the GTP-bound state of mutant KRASG12C, with high potency for KRASG12C-CYPA tri-complex formation with an IC50 of 28 nM. It strongly inhibits ERK signaling with an IC50 of 1–10 nM and attenuates AKT/MTOR and RAL pathways, leading to potent suppression of KRASG12C-driven tumor growth and can used in cancer research.
CAS Number
2642037-07-6
Target
Ras
Activity
Apoptosis
Molecular Formula
C57H74N8O7

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