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Fulzerasib

CAT: 0957-E1843-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0957-E1843-01Size:1 mg
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Description
Fulzerasib (IBI351, GFH925) is an irreversible small molecule inhibitor for KRAS G12C mutation blocking KRAS pathway signaling pERK with an IC50 of 37 nM. It demonstrates potent anti-tumor activity in multiple KRAS G12C-mutant tumor models including human pancreatic cancer, human lung adenocarcinoma, colorectal adenocarcinoma, and lung cancer models.
CAS Number
2641747-54-6
Synonyms
IBI351, GFH925
Target
Ras
Activity
Apoptosis
Molecular Formula
C32H30ClFN6O4

Chemical Information

Fulzerasib

Fulzerasib is a small molecule drug. The usage of the INN stem '-rasib' in the name indicates that Fulzerasib is a Ras protein inhibitor. Fulzerasib is under investigation in clinical trial NCT06936644 (A Multicenter, Single-arm Phase II Study to Evaluate the Efficacy and Safety of Fulzerasib (IBI351) in Combination With Ivonescimab (AK-112) in First-line Treatment of Advanced or Metastatic Non-small Cell Lung Cancer Patients With KRAS G12C Mutation). Fulzerasib has a monoisotopic molecular weight of 630.22 Da.

CAS Number2641747-54-6
PubChem CID167713279
IUPAC Name(7R)-16-chloro-15-(2-fluoro-6-hydroxyphenyl)-7,9-dimethyl-12-(4-methyl-2-propan-2-yl-3-pyridinyl)-5-prop-2-enoyl-2,5,9,12,14-pentazatetracyclo[8.8.0.02,7.013,18]octadeca-1(10),13,15,17-tetraene-8,11-dione
Molecular FormulaC33H32ClFN6O4
Molecular Weight631.1
XLogP4.1
Topological Polar Surface Area110
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count45
Formal Charge0
Complexity1270
SMILES
CC1=C(C(=NC=C1)C(C)C)N2C3=NC(=C(C=C3C4=C(C2=O)N(C(=O)[C@@]5(N4CCN(C5)C(=O)C=C)C)C)Cl)C6=C(C=CC=C6F)O
InChI
InChI=1S/C33H32ClFN6O4/c1-7-23(43)39-13-14-40-28-19-15-20(34)26(24-21(35)9-8-10-22(24)42)37-30(19)41(27-18(4)11-12-36-25(27)17(2)3)31(44)29(28)38(6)32(45)33(40,5)16-39/h7-12,15,17,42H,1,13-14,16H2,2-6H3/t33-/m1/s1
InChIKey
BRWVQEWFJJFLIQ-MGBGTMOVSA-N
Chemical Structure
2D Structure
2D structure of Fulzerasib
CAS: 2641747-54-6
CID: 167713279
Formula: C33H32ClFN6O4
MW: 631.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight631.1
XLogP34.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass630.2157594
Monoisotopic Mass630.2157594
Topological Polar Surface Area110 Ų
Heavy Atom Count45
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
T73190-01Fulzerasib
A24228-5Fulzerasib (IBI351, GFH925) 5mg
A24228-1Fulzerasib (IBI351, GFH925) 1mg
A24228-50Fulzerasib (IBI351, GFH925) 50mg
A24228-10Fulzerasib (IBI351, GFH925) 10mg

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