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Auristatin E

CAT: 0957-S0561-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-S0561-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Auristatin E (AE) is a fully synthetic, highly potent antimitotic pentapeptide and a structural analog of dolastatin-10. It inhibits microtubule polymerization, leading to mitotic arrest at the G2/M phase and subsequent apoptotic cell death in tumor cells. Due to its high toxicity, AE is primarily utilized as a cytotoxic payload in antibody–drug conjugates (ADCs), where targeted delivery minimizes systemic toxicity.
CAS Number
160800-57-7
Target
Others
Activity
Others
Molecular Formula
C40H69N5O7

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