NNK (Standard)

• Description :

  NNK (Standard) is the analytical standard of NNK. This product is intended for research and analytical applications. NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].

• UNSPSC :

  12352005

• Target :

  Endogenous Metabolite; Reference Standards

• Type :

  Reference Standards

• Related Pathways :

  Metabolic Enzyme/Protease; Others

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nnk-standard.html

• Smiles :

  O=C(C1=CC=CN=C1)CCCN(C)N=O

• Molecular Formula :

  C10H13N3O2

• Molecular Weight :

  207.23

• References & Citations :

  [1]Jin Z, et al. Tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279 (38) :40209-40219.|[2]Castonguay A, et al. Lung tumorigenicity of NNK given orally to A/J mice: its application to chemopreventive efficacy studies. Exp Lung Res. 1991;17 (2) :485-499.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [64091-91-4]