NNK

• Description :

  NNK is a nicotine-nitrosated derivative. NNK simultaneously stimulates Bcl2 phosphorylation exclusively at Ser70 and c-Myc at Thr58 and Ser62 through activation of both ERK1/2 and PKCα[1]. NNK induces survival and proliferation of human lung cancer cells. NNK can be used for lung cancer mice model structure[2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301, H317, H351

• Target :

  Endogenous Metabolite

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/nnk.html

• Concentration :

  10mM

• Purity :

  99.98

• Solubility :

  DMSO : ≥ 62.5 mg/mL

• Smiles :

  O=C(C1=CC=CN=C1)CCCN(C)N=O

• Molecular Formula :

  C10H13N3O2

• Molecular Weight :

  207.23

• Precautions :

  H301, H317, H351

• References & Citations :

  [1]Jin Z, et al. Tobacco-specific nitrosamine 4- (methylnitrosamino) -1- (3-pyridyl) -1-butanone promotes functional cooperation of Bcl2 and c-Myc through phosphorylation in regulating cell survival and proliferation. J Biol Chem. 2004;279 (38) :40209-40219.|[2]Castonguay A, et al. Lung tumorigenicity of NNK given orally to A/J mice: its application to chemopreventive efficacy studies. Exp Lung Res. 1991;17 (2) :485-499.|[3]Ge GZ, et al. Tobacco carcinogen NNK-induced lung cancer animal models and associated carcinogenic mechanisms. Acta Biochim Biophys Sin (Shanghai) . 2015 Jul;47 (7) :477-87. |[4]Razani-Boroujerdi S, et al. Early manifestations of NNK-induced lung cancer: role of lung immunity in tumor susceptibility. Am J Respir Cell Mol Biol. 2007 Jan;36 (1) :13-9.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [64091-91-4]