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Ziftomenib

CAT: 0957-E1290-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0957-E1290-02Size:5 mg
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Description
Ziftomenib (KO-539) is an oral inhibitor of menin targeting the menin–KMT2A protein-protein interaction. It exhibits antileukemic activity and induces apoptosis of acute myeloid leukemia (AML) cells.
CAS Number
2134675-36-6
Synonyms
KO-539
Target
MLL
Activity
Epigenetics
Molecular Formula
C33H42F3N9O2S2

Chemical Information

Ziftomenib

Ziftomenib is a potent and highly selective menin inhibitor. This drug was approved by the FDA on November 13th, 2025, for the treatment of relapsed or refractory acute myeloid leukemia (AML) in adults with a susceptible NPM1 mutation who have no satisfactory alternative treatment options. Ziftomenib works by preventing the protein-protein interaction between menin and KMT2A, a complex essential for maintaining the proliferation and survival of these leukemic cells.

CAS Number2134675-36-6
PubChem CID138497449
IUPAC Name4-methyl-5-[[4-[[2-(methylamino)-6-(2,2,2-trifluoroethyl)thieno[2,3-d]pyrimidin-4-yl]amino]piperidin-1-yl]methyl]-1-[(2S)-2-(4-methylsulfonylpiperazin-1-yl)propyl]indole-2-carbonitrile
Molecular FormulaC33H42F3N9O2S2
Molecular Weight717.9
XLogP5.6
Topological Polar Surface Area159
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Heavy Atom Count49
Formal Charge0
Complexity1270
SMILES
CC1=C(C=CC2=C1C=C(N2C[C@H](C)N3CCN(CC3)S(=O)(=O)C)C#N)CN4CCC(CC4)NC5=C6C=C(SC6=NC(=N5)NC)CC(F)(F)F
InChI
InChI=1S/C33H42F3N9O2S2/c1-21(43-11-13-44(14-12-43)49(4,46)47)19-45-25(18-37)15-27-22(2)23(5-6-29(27)45)20-42-9-7-24(8-10-42)39-30-28-16-26(17-33(34,35)36)48-31(28)41-32(38-3)40-30/h5-6,15-16,21,24H,7-14,17,19-20H2,1-4H3,(H2,38,39,40,41)/t21-/m0/s1
InChIKey
BGGALFIXXQOTPY-NRFANRHFSA-N
Chemical Structure
2D Structure
2D structure of Ziftomenib
CAS: 2134675-36-6
CID: 138497449
Formula: C33H42F3N9O2S2
MW: 717.9
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight717.9
XLogP35.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count14
Rotatable Bond Count10
Exact Mass717.28549845
Monoisotopic Mass717.28549845
Topological Polar Surface Area159 Ų
Heavy Atom Count49
Formal Charge0
Complexity1270
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C01598-100mgZiftomenib
CS-O-63466Ziftomenib-d8
A24338-10Ziftomenib (KO-539) 10mg
A24338-100Ziftomenib (KO-539) 100mg
A24338-50Ziftomenib (KO-539) 50mg
A24338-5Ziftomenib (KO-539) 5mg

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