GLRB Polyclonal Antibody

• Background :

  Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346) . Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357) . Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346) . Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488) .

• Synonyms :

  Glycine receptor subunit beta; GLRB; Glycine receptor 58 kDa subunit

• Gene ID :

  2743

• Swiss Prot :

  P48167

• Cellular Locus :

  Cytoplasm, Cell membrane

• Host :

  Rabbit

• Cross Reactivity :

  Mouse, Rat

• Immunogen :

  51-150/497

• Target :

  GLRB

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human GLRB

• Applications :

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification :

  Purified by Protein A.

• Concentration :

  1ug/ul

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Prediction Reactivity :

  Human, Dog, Cow, Sheep, Pig, Horse, Rabbit

• Gene ID URL :

  2743

• Isotype :

  IgG