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DYH5 rabbit pAb

CAT: 0855-ES16870-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009]
Description
This gene encodes a dynein protein, which is part of a microtubule-associated motor protein complex consisting of heavy, light, and intermediate chains. This protein is an axonemal heavy chain dynein. It functions as a force-generating protein with ATPase activity, whereby the release of ADP is thought to produce the force-producing power stroke. Mutations in this gene cause primary ciliary dyskinesia type 3, as well as Kartagener syndrome, which are both diseases due to ciliary defects. [provided by RefSeq, Oct 2009],
UniProt
Q8TE73
Swiss Prot
Q8TE73
Reactivity
Human; Mouse
Immunogen
Synthesized peptide derived from human DYH5 AA range: 2445-2495
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF
Concentration
1 mg/ml
Dilution
IHC-p 1: 50-200
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasm, cytoskeleton, cilium axoneme .
Gene ID (Human)
1767

UniProtKB · Q8TE73

Dynein axonemal heavy chain 5

DYH5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8TE73
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
DNAH5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
Q92860, Q96L74, Q9H5S7, Q9HCG9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

ATP-bindingNucleotide-binding

Cellular component

Cell projectionCiliumCytoplasmCytoskeletonDyneinMicrotubule

Disease

CiliopathyDisease variantKartagener syndromePrimary ciliary dyskinesia

Domain

Coiled coilRepeat

Molecular function

Motor protein