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Recombinant human IKBKB protein

CAT: 0498-bs-42351P-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0498-bs-42351P-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IKK beta (I-Kappa-B kinase-beta) is a member of the IKK complex which is composed of IKK alpha, IKK beta, IKK gamma and IKAP. Phosphorylation of I-Kappa-B on a serine residue by the IKK complex frees NF-kB from I-Kappa-B and marks it for degradation via ubiquination. IKK beta has been shown to activate NF-kB and phosphorylate IKB alpha and beta. Phosphorylation of 2 sites at the activation loop of IKK beta is essential for activation of IKK by TNF and IL1. Once activated, IKK beta autophosphorylates which in turn decreases IKK activity and prevents prolonged activation of the inflammatory response. Additionally, IKK beta activity can also be regulated by MEKK1.
Gene ID
3551
Swiss Prot
O14920
Expression System
E.coli
Conjugation
Unconjugated
Tag
N-His-Avi
Source
Recombinant human IKBKB protein is expressed in E.coli with N-Trx-His. It contains the amino acid sequence of 1-256/756
Applications
Others
Endotoxin
Not Tested
Purity
> 90% as determined by SDS- PAGE
Buffer
20mM Tris-HCl (pH8.0) with 2M Urea.
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
Others
Gene ID URL
3551

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