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Recombinant mouse TLR4 protein

CAT: 0498-bs-42034P-01Size: 20 µgDry Ice: NoHazardous: No
CAT#:0498-bs-42034P-01Size:20 µg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. In silico studies have found a particularly strong binding of surface TLR4 with the spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of Coronavirus disease-2019 (COVID-19) . This receptor has also been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness, and with susceptibility to age-related macular degeneration. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
Gene ID
7099
Swiss Prot
Q9QUK6
Expression System
E.coli
Conjugation
Unconjugated
Tag
N-His
Source
Recombinant mouse TLR4 protein is expressed in E.coli with N-His. It contains the amino acid sequence of 26-629/835
Applications
Others
Endotoxin
Not Tested
Purity
> 90% as determined by SDS- PAGE
Buffer
0.01M TBS (pH7.4)
Storage Conditions
The product should be stored at -70°C or -20°C.
Species
Others
Gene ID URL
7099

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