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CD105 Antibody (Biotin)

CAT: 0013-GTR17857414Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR17857414Size:0.1 mg
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Description
Mouse monoclonal antibody conjugated to Biotin which recognizes CD105 that also known as Endoglin, is a Type I transmembrane protein, which is highly expressed on human vascular endothelial cells. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1) . It is a major glycoprotein of vascular endothelium. It may play a critical role in the binding of endothelial cells to integrins and/or other RGD receptors.
Product Name Alternative
Endoglin, END, ENG, HHT1, ORW1
UniProt
P17813
Reactivity
Human, Porcine
Immunogen
Recombinant Vaccinia virus containing the human CD105 (L-isoform) cDNA.
Target
CD105
Clonality
Monoclonal
Clone
MEM-229
Conjugation
Biotin
Field of Research
Cardiovascular Research; Immunology & Inflammation
Purification
Purified antibody is conjugated with biotin LC-NHS ester under optimum conditions and unconjugated antibody and free biotin are removed by size-exclusion chromatography.
Concentration
1 mg/ml
Storage Conditions
Store at 2-8°C. Do not freeze.
Notes
For research use only.
Applications Notes
Flow cytometry: Recommended dilution: 8 μg/ml; positive control: Kg1 human acute myelogenous leukemia cell line.
Tested Applications
FC, ICC, IHC-Fr, WB
Preservative
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Isotype
Mouse IgG2a
Entrez
2022

UniProtKB · P17813

Endoglin

EGLN_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P17813
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ENG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q14248, Q14926, Q5T9C0
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

AngiogenesisCell adhesion

Cellular component

Cell membraneMembrane

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPhosphoprotein

Domain

SignalTransmembraneTransmembrane helix

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