XI-011

• Background:

  XI-011 activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX) .1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4

• Conjugation:

  Unconjugated

• Buffer:

  Yellow solid

• Storage Conditions:

  -20°C