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XI-011

CAT: 0498-bs-83760C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83760C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
XI-011 activates p53 by inhibiting expression of one of its negative regulators, MDM4 (MDMX) .1 It was able to induce apoptosis in MCF-7 breast cancer cells. XI-011 acted synergistically with cisplatin in inducing apoptosis in head and neck cancer cells.2 It also induced apoptosis in several cervical cancer in vitro and in vivo.3 XI-011 displayed efficacy in treating lung fibrosis in an MDM4-dependent manner.4
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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