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E3330

CAT: 0498-bs-83746C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83746C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E3330 is a hepatoprotective benzoquinone that inhibits TNF-α release via decreasing NFkB activation.1,2 It also is an inhibitor of AP endonuclease 1 (APE1) redox function.3 E3330 acts synergistically with cisplatin to increase cytotoxicity and impair cell migration and invasion in non-small cell lung cancer.4 Inhibition of APE1 with E3330 induces ferroptosis via impairment of AKT phosphorylation ultimately leading to Nrf2 degradation.5 It sensitizes osteosarcoma cells to ionizing radiation via ferroptosis induction.6
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C

Alternative Products

CatalogName
MBS3840368-01E3330
A14440-10E3330 10mg
A14440-100E3330 100mg
A14440-2E3330 2mg
A14440-500E3330 500mg
A14440-50E3330 50mg
A14440-5E3330 5mg
A14440-200E3330 200mg
A14440-25E3330 25mg
A14440-1E3330 1mg

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