Calphostin C

• Background:

  Potent and specific inhibitor of protein kinase C (PKC, IC50 = 50 nM) .1 Inhibition of PKC is light dependent2 and is competitive with the diacylglycerol / phorbol ester binding site1. Calphostin C competes with the diacylglycerol / phorbol ester binding site in other proteins such as Munc13-1.3 Reverses oxycodone-induced tolerance to respiratory depression.4

• Conjugation:

  Unconjugated

• Buffer:

  Dark red to light brown solid

• Storage Conditions:

  -20°C