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10074-G5

CAT: 0498-bs-83447C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83447C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibits c-Myc by disrupting c-Myc/Max heterodimer formation and inhibiting its transcriptional activity.1 10074-G5 binds to the c-Myc bHLHZip domain with Kd=2.8 mM.1 It was cytotoxic in C-Myc-overexpressing cell lines (IC50s = 13 to 15 mM) but was not active in vivo due to rapid metabolism.2 10074-G5 is a useful tool to probe for involvement of c-Myc involvement in cellular processes.3,4 Binds to and sequesters the intrinsically disordered amyloid-β (Aβ) in its monomeric soluble state and rescues a C. elegans model of Aβ-associated toxicity.5
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C

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A17169-10010074-G5 100mg
A17169-50010074-G5 500mg
A17169-5010074-G5 50mg
A17169-210074-G5 2mg
A17169-510074-G5 5mg
A17169-1010074-G5 10mg
A17169-20010074-G5 200mg
HY-100996R10074-G5 (Standard)

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