CR8 3HCl (R)

CAT: 0498-bs-83440C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83440C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Second generation analog of roscovitine which inhibits cyclin-dependent kinases with increased potency, Cdk1/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk5, p25, and Cdk9/cyclin T, IC50s=0.09, 0.072, 0.041, 0.11 and 0.18 M respectively.1,2 Acts as a molecular glue degrader that depletes cyclin K.3 CR8 displays neuroprotective effects in various models including traumatic brain injury.4

Conjugation

Unconjugated

Buffer

White or off-white solid

Storage Conditions

-20°C

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CR8 3HCl (R)

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