Rebastinib

CAT: 0498-bs-83408C-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0498-bs-83408C-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

Rebastinib is a potent ABL1 kinase inhibitor (IC50 = 0.8 nM) that binds to amino acid residues that are used to switch between active and inactive conformations.1 It inhibits both phosphorylated and unphosphorylated ABL1 as well as gatekeeper mutant T315I (IC50 = 4 nM) . Rebastinib was active against chronic myeloid leukemia Ba/F3 cells expressing BCR-ABL (IC50 = 19 nM) and BCR-ABLT315I (IC50 = 63 nM) and most kinase mutants.2 Rebastinib has been reported to inhibit the growth and metastasis of xenografted MDA-MB-231 triple-negative breast cancer cells by targeting AXL/MET.3 It has also been shown to be a potent inhibitor of Tie2 kinase (IC50 = 0.63 nM) .4 Rebastinib blocked necroptosis via inhibition of RIPK1 and RIPK3.5

Conjugation

Unconjugated

Buffer

White to off-white solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
HY-13024-01	Rebastinib
B1404-50	DCC-2036 (Rebastinib)
S2634-10mg	Rebastinib (DCC-2036)
MBS130966-01	DCC-2036(Rebastinib)

Rebastinib

Alternative Products

Popular Products