Products for Research Use Only

P505-15

CAT: 0498-bs-83404C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83404C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
P505-15 is a highly selective and potent (IC50 = 1-2 nM) inhibitor of spleen tyrosine kinase (Syk) .1 It potently inhibited B cell antigen receptor-mediated B cell signaling/activation and basophil degranulation. It displayed anti-inflammatory activity in rodent models of rheumatoid arthritis. P505-15 displayed efficacy in vitro and in vivo in non-Hodgkin lymphoma and chronic lymphocytic leukemia models.2,3 It protected against toxin-induced hepatic fibrosis, associated hepatocellular injury, and hepatocarcinogenesis.4 P505-15 was also found to inhibit PINK1 (IC50 = 0.5-3 µM) in HeLa cells and dopaminergic neurons.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C