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EFT508

CAT: 0498-bs-83375C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83375C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
EFT508 is a potent (IC50s = 2.4 nM MNK1; 1.0 nM MNK2) and highly selective inhibitor of the mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2), key regulators of mRNA translation protein eukaryotic initiation factor eIF4E.1 It potently inhibits phosphorylation of eIF4E in multiple solid and hematological tumor lines leading to blockade of pro-inflammatory and pro-tumorigenic cytokine production. eFT508 reversed the aggressive and metastatic characteristics of mouse liver cancer via inhibition of PD-L1 upregulation.2 Displays inhibitory effects in various cancers models including acute myeloid leukemia3, gastric4, and breast5. eFT-508 has also shown efficacy in treating neuropathic pain via the MNK-eIF4E pathway.6,7,8
Conjugation
Unconjugated
Buffer
Pale yellow solid
Storage Conditions
-20°C

Alternative Products

CatalogName
abx283501-01EFT508
MBS131605eFT508 (eFT-508; eFT 508)

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