GSK4112

CAT: 0498-bs-83126C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83126C-01Size:5 mg
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Background
Selective Rev-Erbα agonist (EC50=250 nM) .1,2 It induces circadian clock phase shifts in isolated primary lung fibroblasts as well as in lung slices (10 µM) .1 GSK4112 showed an inhibitory effect on the amplitude of circadian oscillations and caused an arrhythmic expression of canonical clock genes.3 In murine RAW264 macrophages it suppressed inflammatory functions via repressing Ccl2 expression.4 It protected RANKL-induced bone loss via inhibition of osteoclast differentiation in vivo.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
C10782GSK4112
A17135-10GSK4112 10mg
A17135-50GSK4112 50mg
A17135-5GSK4112 5mg
A17135-200GSK4112 200mg
A17135-25GSK4112 25mg
A17135-100GSK4112 100mg
TBI5493-5MGGSK4112, Rev-Erbalpha agonist
A17135-10mM-DGSK4112 10mM * 1mL in DMSO

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