GSK8612

CAT: 0498-bs-82992C-01Size: 5 mgDry Ice: NoHazardous: No

CAT#:0498-bs-82992C-01Size:5 mg

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PRICE

AVAILABILITY: InStock

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMC’s (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells) .

Conjugation

Unconjugated

Buffer

Beige solid

Storage Conditions

-20°C

Related Products

Catalog	Name
bs-83126C-01	GSK4112
bs-83050C-01	GSK872

Alternative Products

Catalog	Name
BUP12736-01	GSK8612
A19438-10	GSK8612 10mg
A19438-5	GSK8612 5mg
A19438-1	GSK8612 1mg
A19438-2	GSK8612 2mg
A19438-50	GSK8612 50mg
A19438-100	GSK8612 100mg
A19438-25	GSK8612 25mg
A19438-10mM-D	GSK8612 10mM * 1mL in DMSO
TBI4693-5MG	GSK8612, TBK1 inhibitor (highly selective)

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