Chroman 1

• Background :

  Extremely potent inhibitor of Rho kinase II (ROCK-II) 1,2 – it displayed greater selectivity and potency compared to Y-27632 (IC50’s: ROCK I = 52 pM/ROCK II = 1 pM; Y-27632 IC50’s: ROCK I = 71 nM/ROCK II = 46 nM) 3. Chroman 1, used in conjunction with trans-ISRIB (Cat# 10-1539), Emricasan (Cat# 10-4280), and polyamines (CEPT cocktail), promotes cytoprotective cell survival in human pluripotent stem cells (hPSCs) and was found to superior to Y-27632.3 Chroman 1 is an important new tool in the generation and maintenance of stem cells.

• Conjugation :

  Unconjugated

• Buffer :

  White solid

• Storage Conditions :

  -20°C