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Larotrectinib

CAT: 0498-bs-83042C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83042C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Larotrectinib is a potent (IC50’s < 11 nM) inhibitor of tropomyosin receptor kinases A, B, and C (TrkA, B, and C) .1 It is >100 fold selective against a panel of 229 kinases. Larotrectinib markedly attenuated bone cancer pain and significantly blocked the formation of neuroma-like structures and the sprouting of sensory nerve fibers. Larotrectinib caused substantial tumor regression in various cancers displaying TRK gene fusions.2-4 Larotrectinib is the first tissue agnostic drug approved by the FDA.
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
RT

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