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Firsocostat

CAT: 0498-bs-82996C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82996C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent (IC50 = 1.7 nM ACC1; 2.6 nM ACC2) allosteric protein-protein interaction inhibitor of acetyl-CoA carboxylase (ACC) .1 It interacts with the ACC phosphopeptide acceptor and dimerization site to inhibit enzymatic activity resulting in decreased fatty acid synthesis and stimulation of fatty acid oxidation. It reduced hepatic steatosis, improves insulin sensitivity, reduces weight gain, and favorably affects dyslipidemia in rats. Firsocostat decreased hepatic steatosis and fibrosis markers in patients with nonalcoholic fatty liver disease.2 Directly impairs profibrinogenic activity of hepatic stellate cells (HSC) via prevention of induction of glycolysis and oxidative phosphorylation during HSC activation.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-16901-01Firsocostat
A21000-50Firsocostat 50mg
A21000-25Firsocostat 25mg
HY-16901R-01Firsocostat (Standard)
A21000-500Firsocostat 500mg
A21000-100Firsocostat 100mg
A21000-10Firsocostat 10mg
A21000-5Firsocostat 5mg
A21000-2Firsocostat 2mg
A21000-1Firsocostat 1mg

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