Necrostatin-34

CAT: 0498-bs-82988C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82988C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Necrostatin-34 is a selective inhibitor of RIP1 kinase. IC50s = 667 nM and 134 nM for TNFα in FAD-deficient Jurkat cells and L929 cells respectively. It binds to a site distinct from that of 7-Cl-O-Nec1 (Focus Cat# 10-4544) locking the enzyme in an inactive conformation. Necrostatin-34 acts synergistically with 7-Cl-O-Nec1 to inhibit necroptosis.

Conjugation

Unconjugated

Buffer

Off-white solid

Storage Conditions

-20°C

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Necrostatin-34

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