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PB28 dihydrochloride

CAT: 0498-bs-82976C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82976C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PB28 is a very potent high affinity (Ki = 5.3 nM1, 0.34 nM2) sigma 2 agonist. Selective for sigma 2 over sigma1 (approx 30-40x) .1,2 PB28 inhibited cell growth in MCF7 and MCF7 ADR breast cancer cells and displayed strong synergism with doxorubicin.3 PB28 potently inhibited Kv2.1 currents in a sigma-independent manner.4 PB28 was recently found to have potent (IC50 = 280 nM) anti-SARS-CoV2 activity.5
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C

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