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ML365

CAT: 0498-bs-82973C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82973C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ML365 is a potent (IC50 = 16 nM) and selective (62-fold selective over TASK-3) blocker of the two-pore domain potassium channel K2P3.1 (TASK-1) .1 It also less potently (IC50 = 4.07 µM) blocks the K2P6.1 (TWIK-2) channel resulting in blocking the ATP-induced NLRP3 inflammasome.2 ML365 improved the efficacy of Levetiracetam in chronically epileptic rats.3 It suppressed the release of TNF-α, IL-6, and IL-1ß in an LPS-induced inflammatory model via regulation of NF-kB signaling.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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A21736-10mM-DML365 10mM * 1mL in DMSO
TBI4658-5MGML365, Potent and selective K2P3.1 blocker

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