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VU0134992

CAT: 0498-bs-82967C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82967C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
VU0134992 is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM) .1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats suggesting therapeutic blood pressure lowering potential. It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2
Conjugation
Unconjugated
Buffer
Off-white/tan solid
Storage Conditions
-20°C

Alternative Products

CatalogName
BUP08912-01VU0134992
CSB51591-01Vu0134992 (hydrochloride)
A18593-50VU0134992 50mg
A18593-1VU0134992 1mg
M22026-01VU0134992 hydrochloride
A18593-200VU0134992 200mg
A18593-100VU0134992 100mg
A18593-25VU0134992 25mg
A18593-10VU0134992 10mg
A18593-5VU0134992 5mg

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