VU0134992 (hydrochloride)

• UNSPSC Description:

  VU0134992 hydrochloride is the first subtype-preferring, orally active and selective Kir4.1 potassium channel pore blocker, with an IC50 of 0.97 μM. VU0134992 hydrochloride is 9-fold selective for homomeric Kir4.1 over Kir4.1/5.1 concatemeric channels (IC50=9 μM) at -120 mV[1].

• Target Antigen:

  Potassium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/vu0134992-hydrochloride.html

• Purity:

  98.34

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)|H2O : 2.27 mg/mL (ultrasonic;warming;heat to 60°C)

• Smiles:

  O=C(NC1CC(C)(C)NC(C)(C)C1)COC2=CC=C(C(C)C)C=C2Br.[H]Cl

• Molecular Weight:

  447.84

• References & Citations:

  [1]Kharade SV, et al. Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992. Mol Pharmacol. 2018 Aug;94(2):926-937.Biochim Biophys Acta Mol Basis Dis. 2023 Mar 28;1869(5):166700.|Nat Commun. 2022 Nov 21;13(1):7136.|Glia. 2021 Jun 21.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  1052515-91-9