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R162

CAT: 0498-bs-82940C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82940C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
R162 (64302-87-0) is a selective inhibitor of glutamate dehydrogenase 1 (GDH1), a commonly upregulated enzyme in human cancers (Ki = 28.6 µM) . It does not inhibit the activity of other NADPH enzymes such as 6-phosphogluconate dehydrogenase and fumarate hydratase. R162 treatment lead to decreased fumarate levels, lower glutathione peroxidase activity, increased ROS levels and reduced cell proliferation in H1299 and MDA-MB231 cells. R162 sensitizes LKB-1 deficient tumor cells to anoikis induction. R162 treatment (at 20 mg/kg/day) significantly attenuates metastatic potential in a xenograft mouse model.2 GDH1 is a promising antimetastasis target and R162 us a useful tool for proof of principal studies.
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
E1170-25mgR162
A19685-50R162 50mg
A19685-2R162 2mg
A19685-1R162 1mg
A19685-10R162 10mg
A19685-500R162 500mg
A19685-100R162 100mg
A19685-25R162 25mg

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