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TH588

CAT: 0498-bs-82939C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82939C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
TH588 is a first-in-class nudix hydrolase family inhibitor.1 MTH1/NUDT1 is a family member that “sanitizes” oxidized deoxynucleotide triphosphates (dNTP) preventing their incorporation into DNA and thus avoiding DNA damage and cell death. TH588 inhibits MTH1/NUDT1 (IC50 = 5 nM) leading to cell death in several cancer cell lines while not affecting normal cells. Active in vitro and in vivo. Recent evidence has raised doubts about the cancer-killing ability of MTH1 inhibition.2,3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
B5845-5.1TH588
T60984-01TH588 hydrochloride
A15537-2TH588 2mg
HY-12814ATH588 (hydrochloride)
A15537-25TH588 25mg
A15537-5TH588 5mg
HY-12814RTH588 (Standard)
A15537-100TH588 100mg

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