THZ1

CAT: 0498-bs-82800C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82800C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

THZ1 is an irreversible, covalent inhibitor (dual ATP-site and allosteric covalent binding) of CDK7 (IC50 = 15.6nM @ 20min and 3.2nM @ 180 min) .1 It displayed broad based antiproliferative activity with IC50’s of less than 200nM against 53% of the 1000 cancer cell lines it was tested against. THZ1 disrupts transcription of several proteins including RUNX1, TAL1, and GATA3. It suppresses oncogenic transcription of MYCN-driven cancers.2 THZ1 decreases STAT3 chromatin binding and expression of target genes such as MYC, PIM1, and others in peripheral T-Cell lymphoma cells with the Y640F STAT3 mutation.3 Addition of THZ1 to targeted cancer therapy increases cell death and hinders the development of drug-resistant cell populations in cellular and in vitro cancer models.4

Conjugation

Unconjugated

Buffer

Tan solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
HY-80013-01	THZ1
B4736-10	THZ1 Hydrochloride
467607-01	THZ1-d6
S7549-1g	THZ1 2HCl
BA3820-5.1	THZ1-R
HY-80013A-01	THZ1 (Hydrochloride)
HY-128867-01	Bio-THZ1

THZ1

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