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ML277

CAT: 0498-bs-82785C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82785C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ML277 is a potent (EC50 = 260 nM) activator of Kv7.1 with selectivity against Kv7.2, Kv7.4, and Kv11.1 (hERG) .1 ML277 enhances cardiac delayed rectifier K+ currents (IKs) in human iPSC-derived cardiomyocytes from normal and long QT-interval syndrome afflicted patients suggesting potential therapeutic use in long QT-interval syndrome.2,3 It displayed cardioprotective effects against ischemia in cellular and whole-heart models.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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