SGC-iMLLT

• Background:

  Potent (IC50 = 260 nM) inhibitor of the YEATS domain of MLLT1/3.1 YEATS domain containing proteins bind acetyl and crotonyl marks on histone tails. Selective against the two other human YEATS domains YEATS2/4 and 48 bromodomains. YEATS containing MLL-ENL leukemic cells display increased sensitivity to SGC-iMLLT versus control AML cells.2

• Conjugation:

  Unconjugated

• Buffer:

  Off-white to beige solid

• Storage Conditions:

  -20°C