Products for Research Use Only
RegisterLogin

LMK235

CAT: 0498-bs-82765C-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-82765C-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Potent and selective inhibitor of HDAC4 (IC50 = 11.9 nM) and HDAC5 (IC50 = 4.2 nM) .1 Cytotoxic against human ovarian cancer cell lines A2780 and A2780 CisR (IC50’s = 0.49 µM and 0.32 µM respectively) . It displayed synergistic effects with cisplatin and restored sensitivity in platinum-resistant cell lines.1,2 LMK235 induced apoptosis in pancreatic neuroendocrine tumor cell lines BON-1 and QGP-13 and in multiple myeloma cells4. It also induced autophagy and cell death via SCNN1A downregulation in glioblastoma cells.5 LMK235 reduced hypertension in mouse and rat models via inhibition of vascular constriction and vessel hypertrophy.6 LMK235 significantly increased neurite outgrowth via increased BMP-Smad-dependent transcription in SH-SY5Y cells and exerted neuroprotective effects against neurodegeneration induced by MPP+ suggesting possible therapeutic potential in treating Parkinson’s disease.7
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

Alternative Products

CatalogName
GTR19171782-01LMK235
TBI4024-5MGLMK235, Potent, selective inhibitor of HDAC4/5

Popular Products