Brequinar sodium

CAT: 0498-bs-82740C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82740C-01Size:10 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Brequinar sodium is an inhibitor of dihydroorotate dehydrogenase (DHODH) 1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5,6,7
Conjugation
Unconjugated
Buffer
White to off-white solid
Storage Conditions
-20°C

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217314Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2- (2’-fluoro-1,1’-biphenyl-4-yl) -3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785)
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