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Brequinar sodium

CAT: 0498-bs-82740C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82740C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Brequinar sodium is an inhibitor of dihydroorotate dehydrogenase (DHODH) 1,2 with IC50’s between 0.2 and 5.8 µM in various cell lines3 and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4 Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5,6,7
Conjugation
Unconjugated
Buffer
White to off-white solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
B2637-25Brequinar Sodium
HY-108325ABrequinar (sodium)
330037Brequinar sodium hydrate
6196/10Brequinar sodium 10 mg
6196/50Brequinar sodium 50 mg
TBI3965-10MGBrequinar sodium, Dihydroorotate dehydrogenase inhibitor, antiviral
217314Dihydroorotate Dehydrogenase Inhibitor, Brequinar (6-fluoro-2- (2’-fluoro-1,1’-biphenyl-4-yl) -3-methyl-4-quinoline-carboxylic Acid Sodium Salt, NSC 368390, DuP 785)
HY-108325-01Brequinar

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