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Brequinar

CAT: 0804-HY-108325-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-108325-01Size:5 mg
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Description
Brequinar (DUP785) is a potent inhibitor of dihydroorotate dehydrogenase (DHODH) with an IC50 of 5.2 nM for human DHODH. Brequinar has potent activities against a broad spectrum of viruses. Brequinar also has an anti-SARS2 activity.
CAS Number
[96187-53-0]
Product Name Alternative
DUP785; NSC 368390
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dihydroorotate Dehydrogenase; DNA/RNA Synthesis; SARS-CoV; Virus Protease
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/Brequinar.html
Purity
99.89
Solubility
DMSO : 25 mg/mL (ultrasonic) |Ethanol : < 1 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=C(C)C(C2=CC=C(C3=CC=CC=C3F)C=C2)=NC4=CC=C(F)C=C14)O
Molecular Formula
C23H15F2NO2
Molecular Weight
375.37
Precautions
H302, H315, H319, H335
References & Citations
[1]Schnellrath LC, et al. Potent antiviral activity of brequinar against the emerging Cantagalo virus in cell culture. Int J Antimicrob Agents. 2011 Nov;38 (5) :435-41.|[2]Qing M, et al. Characterization of dengue virus resistance to brequinar in cell culture. Antimicrob Agents Chemother. 2010 Sep;54 (9) :3686-95.|[3]Xu X, et al. In vitro and in vivo mechanisms of action of the antiproliferative and immunosuppressive agent, brequinar sodium. J Immunol. 1998 Jan 15;160 (2) :846-53.|[4]Zeping Zuo, et al. Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production. J Med Chem. 2020 Jun 4.|[5]David C Schultz, et al. Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2. Nature. 2022 Feb 7.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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