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E7820

CAT: 0498-bs-82735C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82735C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
E7820 is an angiogenesis inhibitor that suppresses expression of integrins α2, α3, α5, and ß1.1 Broad-spectrum antitumor and antiangiogenic effects are mainly mediated via integrin α2 suppression.2 E7820 has been identified as a molecular glue that induces proteasomal degradation of the U2AF-related splicing factor CAPERα (RBM39) via CRL4DCAF15 mediated ubiquitination in human cancer cell lines.3,4 E7820 has also been shown to induce degradation of the aryl hydrocarbon receptor nuclear translator (ARNT), a protein essential in maintaining cellular homeostasis in response to environmental stress.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
BA4578-100E7820
A15456-200E7820 200mg

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