Iberdomide

CAT: 0498-bs-82728C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-82728C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Iberdomide is a modulator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex with higher affinity (IC50 = 60 nM) than lenalidomide and pomalidomide leading to more potent degradation of Ikaros (IKZF1; EC50 = 1 nM) ) and Aiolos (IKZF3; EC50 = 0.5 nM) .1 It is more specific for the cereblon complex and does not degrade GSPT1 of CK1α. It displays antitumor and immunostimulatory activity in lenalidomide- and pomalidomide-resistant multiple myeloma cells.2 Iberdomide has also shown efficacy in treating the autoimmune disease cutaneous lupus erythematosus (CLE) .3 It was also shown to act as an HIV-1 latency reversal agent in in CD4+ T-cells.4

Conjugation

Unconjugated

Buffer

White solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
BA2731-100	Iberdomide
A20373-1	Iberdomide 1mg
C13648-01	Iberdomide (CC220)
HY-101291R-01	Iberdomide (Standard)
A20373-5	Iberdomide 5mg
A20373-500	Iberdomide 500mg
A20373-50	Iberdomide 50mg
A20373-25	Iberdomide 25mg

Iberdomide

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