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Tafamidis

CAT: 0498-bs-82707C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82707C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A potent and selective transthyretin (TTR) kinetic stabilizer. It binds selectively and with negative cooperativity to the two normally unoccupied thyroxine binding sites of the TTR tetramer (Kd = ~2 and ~200 nM) 1. Stabilizes wild-type and mutant TTR under varying conditions in vitro (EC50=2.7-3.2 M) .1 Clinically useful for the treatment of familial amyloid polyneuropathy2,3 and TTR-related cardiomyopathy4.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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CatalogName
BA8568-100Tafamidis

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