CPI-613

CAT: 0498-bs-82689C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82689C-01Size:5 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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Alternative Products

CatalogName
MBS384559-01CPI-613
5348/50CPI 613
A11786-25CPI-613 25mg
A11786-50CPI-613 50mg
S2776-50mgDevimistat (CPI-613)
A11786-5CPI-613 5mg
A11786-10CPI-613 10mg
A11786-100CPI-613 (Devimistat) 100mg
A11786-500CPI-613 (Devimistat) 500mg
A11786-10mM-DCPI-613 10mM * 1mL in DMSO

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