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CPI-613

CAT: 0498-bs-82689C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82689C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Lipoic acid analog which potently disrupts mitochondrial metabolism with selectivity for tumor cells in vitro and shows strong antitumor activity in vivo.1 Inhibits alpha-ketoglutarate dehydrogenase (KGDH) by a redox mechanisms selectively in tumor cells.2 Inhibits pyruvate dehydrogenase (PDH) as a mechanistically distinct, non-redox, effect.1,2 A novel anticancer agent with a mitochondria-targeted mode of action with non-genotoxic propertie.3. Has been used (along with PS48) to induce a Warburg-like metabolic state in fibroblasts.4 Combination treatment of CPI-613 and chloroquine inhibits the progression of clear cell sarcoma in a mouse model.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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A4333-5CPI-613
255043-01CPI 613
S2776-10mM/1mLDevimistat (CPI-613)
A11786-50CPI-613 50mg
A11786-25CPI-613 25mg
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A11786-5CPI-613 5mg

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