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PLX-4032

CAT: 0498-bs-82612C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82612C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
An ATP-competitive inhibitor of mutant V600E/F and wild type B-Raf, IC50s=31 and 100 nM respectively.1 Induced growth inhibition, G0/G1 arrest and apoptosis in a variety of cancer cell lines, with a B-Raf mutation favoring but not guaranteeing a response.2 Inhibits the growth of B-Raf V600E-positive melanomas in vitro and in vivo.3 Treatment of patients that carry the V600E BRAF mutation resulted in complete or partial tumor regression.4
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C

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