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Probucol

CAT: 0498-bs-82555C-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0498-bs-82555C-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Probucol (23288-49-5) is a unique antilipidemic drug which inhibits the oxidation of LDL cholesterol preventing the genesis of macrophage-derived foam cells and thus suppressing the formation of atherosclerotic vascular lesions.1 It inhibits ABCA1-mediated cholesterol efflux without influencing scavenger receptor (class B type 1) -mediated efflux.2 It enhances mitophagy and improves survival, locomotor function and dopaminergic neuron loss in zebrafish and fly models of mitochondrial damage.3 It attenuates NF-kB/NLRP3 signaling and augments Nrf-2-mediated antioxidant defense in nerve injury models.4 Improves learning and memory in aging mice.5 It protects neuronal cells against peroxide-induced damage and directly activates glutathione peroxidase-1.6
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
RT

Alternative Products

CatalogName
B2015-SProbucol

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