L-Cycloserine

CAT: 0498-bs-82450C-01Size: 20 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82450C-01Size:20 mg
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Background
L-Cycloserine down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase) .1 The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme.1 It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence.4
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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MBS3842273-01L-Cycloserine
A17324-50L-Cycloserine 50mg
A17324-100L-Cycloserine 100mg
A17324-5L-Cycloserine 5mg
A17324-200L-Cycloserine 200mg
A17324-500L-Cycloserine 500mg

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