CBR-5884

CAT: 0498-bs-82333C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82333C-01Size:5 mg
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Background
Potent and selective inhibitor of 3-phosphoglycerate dehydrogenase (PHGDH), IC50=33 μM1. The action of PHGDH is the first committed step of serine biosynthesis2 and certain cancer cells overexpress PHGDH3. CBR-5884 inhibits serine biosynthesis in cells with no effect on two other dehydrogenases, lactate dehydrogenase and MDH1 and without general cytotoxic effects up to 40 μM. CBR-5884 is selectively toxic to tumor cells with high serine synthesis activity. A novel tool for selective inhibition of serine biosynthesis in cells which also provides further proof that PHGDH is a viable target for the development of novel anticancer agents1.
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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M22643-01CBR-5884
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A16176-5CBR 5884 5mg
A16176-2CBR 5884 2mg
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A16176-10CBR 5884 10mg
A16176-50CBR 5884 50mg
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