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PRT4165

CAT: 0498-bs-82270C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-82270C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1) . Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
RT

Alternative Products

CatalogName
sc-507487PRT4165
217223Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2- (Pyridin-3-ylmethylene) -1H-indene-1,3 (2H) -dione) discontinued

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