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PRT4165

CAT: 0026-B1054-25Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0026-B1054-25Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRT4165 is a potent inhibitor of PRC1 (polycomb-repressive complex 1)-mediated histone H2A ubiquitylation in vivo and in vitro. PRT4165 inhibits the in vitro histone H2A E3 ubiquitin ligase activity of PRC1 components RING1, RNF2, and a BMI1/RNF2 complex. PRT4165 also inhibits DNA double-strand breaks induced ubiquitylation of histone H2AX. In addition, it prevents Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α (Top2α).
Shipping Conditions
gel pack
Storage Conditions
-20°C
Shelf Life
36 months

Alternative Products

CatalogName
sc-507487PRT4165
217223Bmi1-Ring1A E3 Ligase Inhibitor, PRT4165 (2- (Pyridin-3-ylmethylene) -1H-indene-1,3 (2H) -dione) discontinued

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