ML239

CAT: 0498-bs-82231C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82231C-01Size:5 mg
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Background
A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad) . ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3
Conjugation
Unconjugated
Buffer
Beige solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-19971-01ML239
A20619-10ML239 10mg
A20619-25ML239 25mg
A20619-50ML239 50mg
A20619-5ML239 5mg
A20619-100ML239 100mg
A20619-200ML239 200mg
A20619-10mM-DML239 10mM * 1mL in DMSO

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