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SIS17

CAT: 0804-HY-128918-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128918-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SIS17 is a mammalian histone deacetylase 11 (HDAC 11) inhibitor with an IC50 value of 0.83 μM. SIS17 inhibits the demyristoylation of serine hydroxymethyltransferase 2, a substrate of HDAC 11, but does not inhibit other HDACs[1].
CAS Number
2374313-54-7
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/sis17.html
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=CC=CS1)NNCCCCCCCCCCCCCCCC
Molecular Formula
C21H38N2OS
Molecular Weight
366.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Son SI, et al. Activity-Guided Design of HDAC11-Specific Inhibitors. ACS Chem Biol. 2019 Jul 19;14 (7) :1393-1397.|[2]Li R, et al. A pan-cancer analysis identifies HDAC11 as an immunological and prognostic biomarker. FASEB J. 2022 Jul;36 (7) :e22326.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC11

Chemical Information

2-Thiophenecarboxylic acid, 2-hexadecylhydrazide
CAS Number2374313-54-7
PubChem CID139035087
IUPAC NameN'-hexadecylthiophene-2-carbohydrazide
Molecular FormulaC21H38N2OS
Molecular Weight366.6
XLogP8.7
Topological Polar Surface Area69.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count17
Heavy Atom Count25
Formal Charge0
Complexity312
SMILES
CCCCCCCCCCCCCCCCNNC(=O)C1=CC=CS1
InChI
InChI=1S/C21H38N2OS/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18-22-23-21(24)20-17-16-19-25-20/h16-17,19,22H,2-15,18H2,1H3,(H,23,24)
InChIKey
HSHXDCVZWHOWCS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-Thiophenecarboxylic acid, 2-hexadecylhydrazide
CAS: 2374313-54-7
CID: 139035087
Formula: C21H38N2OS
MW: 366.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight366.6
XLogP38.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count17
Exact Mass366.27048501
Monoisotopic Mass366.27048501
Topological Polar Surface Area69.4 Ų
Heavy Atom Count25
Formal Charge0
Complexity312
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C12127-5mgSIS17
BS300164SIS17 - Bio-X TM

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